Plantar Keratoderma with Pachyonychia Likely Induced by Imatinib Mesylate

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Plantar Keratoderma with Pachyonychia Likely Induced by Imatinib Mesylate

526 Ann Dermatol Received September 21, 2012, Revised January 29, 2013, Accepted for publication February 2, 2013 *Hyung Ok Kim and Bo In Lee have equal contribution to this study and are co-first authors of this paper. Corresponding author: Young Min Park, Department of Dermatology, Seoul St. Mary’s Hospital, The Catholic University of Korea College of Medicine, 222 Banpo-daero, Seocho-gu, Seo...

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Imatinib mesylate induced skin hypopigmentation.

Sir, Imatinib mesylate is a tyrosine kinase inhibitor that targets BCR-ABL protein in chronic myelogenous leukemia (CML).1 We present three cases of CML, treated with Imatinib who developed clinical findings of hypopigmentation. All the three patients noticed pigmentation changes after the initiation of therapy with Imatinib mesylate, which was persistent during therapy. The presence of hypopig...

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Imatinib mesylate-induced lichenoid drug eruption.

Imatinib mesylate (imatinib) is a tyrosine kinase inhibitor initially approved by the US Food and Drug Administration in 2001 for chronic myeloid leukemia (CML). Since then, the number of indicated uses for imatinib has substantially increased. It is increasingly important that dermatologists recognize adverse cutaneous manifestations of imatinib and are aware of their management and outcomes t...

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Pityriasis rosea-like Drug Eruption Induced by Imatinib Mesylate (Gleevec™)

Imatinib mesylate (Gleevec™, STI571), a selective inhibitor of BCR-ABL, c-Kit, and platelet-derived factor receptor, has been used to treat chronic myelogenous leukemia (CML) and gastrointestinal stromal tumors. Although its use has been associated with various adverse cutaneous reactions, pityriasis rosea-like drug eruptions are rare. Here, we report a case of pityriasis rosea-like drug erupti...

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Plantar keratoderma of Sézary syndrome

Sézary syndrome is an extremely rare form of cutaneous T-cell lymphoma. It presents suddenly and is associated with a poor prognosis. Clinical recognition is crucial for the diagnostic process and initiation of appropriate treatment. Plantar keratoderma is usually pathognomonic for Sézary syndrome and clinicians should be alerted to its presence.

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ژورنال

عنوان ژورنال: Annals of Dermatology

سال: 2013

ISSN: 1013-9087,2005-3894

DOI: 10.5021/ad.2013.25.4.526